Sourcing high-purity Acetonitrile (HPLC Grade)? ChemicalDekho connects you with major domestic producers like Alkyl Amines and importers of Honeywell/Merck material. Secure critical solvents for analytical laboratories and pharma synthesis.
Acetonitrile (CAS 75-05-8) is the most popular solvent for HPLC because of its low viscosity and high eluting power. In the pharmaceutical industry, it is essential for the production of oligonucleotides and as an extraction solvent for fats and oils. Listings include ultra-pure HPLC/Spectro grades with low UV-cutoff and Technical grades for bulk synthesis.
Buyers can ensure availability of high-purity material with guaranteed transparency and low residue, critical for maintaining column life and result accuracy.
HPLC / LC-MS mobile phase
API Synthesis & Extraction
DNA/Peptide synthesis
Electrolyte component
Fatty acid extraction
Cleaning solvent
Solvent for organic reactions
Leading petrochemical producers
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Highly flammable liquid and vapor. Toxic if swallowed, inhaled, or in contact with skin. Vapor is harmful to eyes. Metabolized into cyanide in the body.
It has low viscosity (reduces back-pressure on the column), good solvating power, and is transparent at low UV wavelengths, which is necessary for detecting analytes.
Yes. It is toxic and, if absorbed or inhaled, can release cyanide into the body. It must be handled in a fume hood with proper PPE.
Acetonitrile is often a byproduct of Acrylonitrile production (plastics). When the plastic industry slows down, ACN supply drops and prices can skyrocket (the 'ACN crisis').
ACN is a stronger solvent and produces better peaks for many molecules, but it is more expensive and toxic than Methanol. Labs choose based on the specific protocol.