Is TMSCl moisture sensitive?

Yes, it reacts violently with water and moisture to produce HCl gas.

What is the primary use in Pharma?

It is used as a protecting group for hydroxyl and amino groups during complex API synthesis.

How should TMSCl be stored?

It must be stored in a cool, dry place under an inert gas blanket to prevent hydrolysis.

Is it available in India?

Yes, it is readily available through major chemical distributors and specialty chemical manufacturers in India.

What PPE is required?

Chemical-resistant gloves, safety goggles, and a face shield are mandatory, along with working in a fume hood.

CHEMICAL DEKHOCD

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Trimethylsilyl Chloride Suppliers In India

CAS: 75-77-4

Formula: C3H9ClSiMolecular Weight: 108.64 g/mol

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Also Known As

Trimethylsilyl Chloride, TMCS

Safety Information

Highly Flammable and Corrosive

Reacts violently with water to release hydrogen chloride gas. Causes severe skin burns and eye damage.

First Aid

Eyes: Rinse cautiously with water for 15 minutes and seek immediate medical attention.

Skin: Remove contaminated clothing and rinse skin with plenty of water.

Applications & Industries

API Synthesis

Silylation reagent for pharmaceutical intermediates

Polymer Modification

Surface treatment agent for silica fillers

Organic Synthesis

Protecting group for hydroxyl and amino groups

Silicone Production

End-capping agent for polydimethylsiloxane chains

Analytical Reagent

Derivatization agent for gas chromatography analysis

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